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Article

UmuD and RecA directly modulate the mutagenic potential of the Y family DNA polymerase DinB.

Molecular cell - 28 Dec 2007

Godoy Veronica G, Jarosz Daniel F, Simon Sharotka M, Abyzov Alexej, Ilyin Valentin, Walker Graham C

Abstract excerpt

DinB is the only translesion Y family DNA polymerase conserved among bacteria, archaea, and eukaryotes. DinB and its orthologs possess a specialized lesion bypass function but also display potentially deleterious -1 frameshift mutagenic phenotypes when overproduced. We show that the DNA damage-inducible proteins UmuD(2) and RecA act in concert to modulate this mutagenic activity. Structural modeling suggests that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18158902
DOI: 10.1016/j.molcel.2007.10.025
PMCID: PMC2265384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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