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Article

NKX2-5 Regulates the Expression of β-Catenin and GATA4 in Ventricular Myocytes

27 May 2009

Abstract excerpt

BACKGROUND: The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin. The interplay between these factors and their downstream targets are not completely understood. Here, we studied regulation of beta-catenin and GATA4 by NKX2-5 in human fetal cardiac myocytes. METHODOLOGY/PRINCIPAL FINDINGS:...

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Identifiers

PMID: 19479054
DOI: 10.1371/journal.pone.0005698

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