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Article

Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.

Development (Cambridge, England) - 1 Jan 1999

Lien C L, Wu C, Mercer B, Webb R, Richardson J A, Olson E N

Abstract excerpt

The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic day 7.5 in the mouse and expression is maintained throughout the developing and adult heart. In addition to the heart, Nkx2-5 is transiently expressed in the developing pharynx, thyroid and stomach. To investigate the...

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Source

Identifiers

PMID: 9834187
DOI: 10.1242/dev.126.1.75

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.PMID 9834187Read ↗

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The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.Semantic proximity Read ↗

An Nkx-dependent enhancer regulates cGATA-6 gene expression during early stages of heart development.Semantic proximity Read ↗

Nkx2.5: a crucial regulator of cardiac development, regeneration and diseasesSemantic proximity Read ↗

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