Article
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
Development (Cambridge, England) - 1 Jan 1999
Lien C L, Wu C, Mercer B, Webb R, Richardson J A, Olson E N
Abstract excerpt
The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first detected in mesodermal cells specified to form heart at embryonic day 7.5 in the mouse and expression is maintained throughout the developing and adult heart. In addition...
Topics
- Animals
- Base Sequence
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- GATA4 Transcription Factor
- Gastric Mucosa
- Gene Expression Regulation, Developmental
- Heart
- Heart Ventricles
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Myocardium
- Regulatory Sequences, Nucleic Acid