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Article

Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.

PloS one - 1 Jan 2019

Dupays Laurent, Towers Norma, Wood Sophie, David Anna, Stuckey Daniel J, Mohun Timothy

Abstract excerpt

The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart function. But little is yet known about the identities of its downstream effectors or their function during differentiation of cardiac progenitor cells (CPCs). We have used transgenic analysis and CRISPR-mediated ablation to identify a cardiac enhancer of the Furin gene. The Furin gene, encoding a...

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Identifiers

PMID: 30840660
DOI: 10.1371/journal.pone.0212992
PMCID: PMC6402701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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