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Article

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery.

Development (Cambridge, England) - 1 Apr 2006

Elliott David A, Solloway Mark J, Wise Natalie, Biben Christine, Costa Mauro W, Furtado Milena B, Lange Martin, Dunwoodie Sally, Harvey Richard P

Abstract excerpt

Homeodomain factor Nkx2-5 is a central component of the transcription factor network that guides cardiac development; in humans, mutations in NKX2.5 lead to congenital heart disease (CHD). We have genetically defined a novel conserved tyrosine-rich domain (YRD) within Nkx2-5 that has co-evolved with its homeodomain. Mutation of the YRD did not affect DNA binding and only slightly diminished transcriptional...

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PMID: 16510504
DOI: 10.1242/dev.02305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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