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Article

Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase.

Chemistry & biology - 29 May 2009

Kapoor Mili, Otero Francella J, Slike Bonnie M, Ewalt Karla L, Yang Xiang-Lei

Abstract excerpt

Aminoacyl tRNA synthetases are known for catalysis of aminoacylation. Significantly, some mammalian synthetases developed cytokine functions possibly linked to disease-causing mutations in tRNA synthetases. Not understood is how epitopes for cytokine signaling were introduced into catalytic scaffolds without disturbing aminoacylation. Here we investigate human tyrosyl-tRNA synthetase, where a catalytic-domain...

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Identifiers

PMID: 19477417
DOI: 10.1016/j.chembiol.2009.03.006
PMCID: PMC2706086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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