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Article

Induction of Angiogenesis by a Fragment of Human Tyrosyl-tRNA Synthetase

1 Jun 2002

Abstract excerpt

The first step of protein synthesis is catalyzed by aminoacyl-tRNA synthetases. In addition, certain mammalian tRNA synthetases link protein synthesis to cytokine signaling pathways. In particular, human tyrosyl-tRNA synthetase (TyrRS) can be split by proteolysis into two fragments having distinct cytokine activities. One of the TyrRS fragments (mini TyrRS) contains features identical to those in CXC chemokines...

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PMID: 11956181
DOI: 10.1074/jbc.c200126200

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