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Article

Gain-of-function mutational activation of human tRNA synthetase procytokine.

Chemistry & biology - 1 Dec 2007

Yang Xiang-Lei, Kapoor Mili, Otero Francella J, Slike Bonnie M, Tsuruta Hiro, Frausto Ricardo, Bates Alison, Ewalt Karla L, Cheresh David A, Schimmel Paul

Abstract excerpt

Disease-causing mutations occur in genes for aminoacyl tRNA synthetases. That some mutations are dominant suggests a gain of function. Native tRNA synthetases, such as tyrosyl-tRNA synthetase (TyrRS) and tryptophanyl-tRNA synthetase, catalyze aminoacylation and are also procytokines that are acti...

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Source

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Identifiers

PMID: 18096501
DOI: 10.1016/j.chembiol.2007.10.016
PMCID: PMC2693404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18096501-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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