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Article

Aminoacyl-tRNA synthetases: Structure, function, and drug discovery.

International journal of biological macromolecules - 1 May 2018

Rajendran Vijayakumar, Kalita Parismita, Shukla Harish, Kumar Awanish, Tripathi Timir

Abstract excerpt

Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein translation. Beyond this classical function, these enzymes are also known to have a role in several metabolic and signaling pathways that are important for cell viability. Study of these enzymes is of great interest to the researchers due...

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PMID: 29305884
DOI: 10.1016/j.ijbiomac.2017.12.157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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