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Article

Aminoacyl-tRNA synthetases in medicine and disease.

EMBO molecular medicine - 1 Mar 2013

Yao Peng, Fox Paul L

Abstract excerpt

Aminoacyl-tRNA synthetases (ARSs) are essential and ubiquitous 'house-keeping' enzymes responsible for charging amino acids to their cognate tRNAs and providing the substrates for global protein synthesis. Recent studies have revealed a role of multiple ARSs in pathology, and their potential use as pharmacological targets and therapeutic reagents. The ongoing discovery of genetic mutations in human ARSs is...

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Identifiers

PMID: 23427196
DOI: 10.1002/emmm.201100626
PMCID: PMC3598075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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