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Article

Correlating amino acid conservation with function in tyrosyl-tRNA synthetase.

Journal of molecular biology - 20 Oct 2000

Xin Y, Li W, Dwyer D S, First E A

Abstract excerpt

Sequence comparisons have been combined with mutational and kinetic analyses to elucidate how the catalytic mechanism of Bacillus stearothermophilus tyrosyl-tRNA synthetase evolved. Catalysis of tRNA(Tyr) aminoacylation by tyrosyl-tRNA synthetase involves two steps: activation of the tyrosine substrate by ATP to form an enzyme-bound tyrosyl-adenylate intermediate, and transfer of tyrosine from the...

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Identifiers

PMID: 11023793
DOI: 10.1006/jmbi.2000.4125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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