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Article

Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase.

Structure (London, England : 1993) - 1 Jul 2007

Yang Xiang-Lei, Guo Min, Kapoor Mili, Ewalt Karla L, Otero Francella J, Skene Robert J, McRee Duncan E, Schimmel Paul

Abstract excerpt

Higher eukaryote tRNA synthetases have expanded functions that come from enlarged, more differentiated structures that were adapted to fit aminoacylation function. How those adaptations affect catalytic mechanisms is not known. Presented here is the structure of a catalytically active natural spl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17637340
DOI: 10.1016/j.str.2007.05.009
PMCID: PMC2104486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17637340-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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