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Article

Aminoacyl tRNA synthetases and their connections to disease.

Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2008

Park Sang Gyu, Schimmel Paul, Kim Sunghoon

Abstract excerpt

Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as aminoacyl tRNA synthetases (AARSs). Surprisingly, the etiology of specific diseases-including cancer, neuronal pathologies, autoimmune disorders, and disrupted metabolic conditions-is connected to specific aminoacyl tRNA synthetases. These...

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Identifiers

PMID: 18682559
DOI: 10.1073/pnas.0802862105
PMCID: PMC2516211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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