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Article

ABCB1 genotypes predict cyclosporine-related adverse events and kidney allograft outcome.

Journal of the American Society of Nephrology : JASN - 1 Jun 2009

Cattaneo Dario, Ruggenenti Piero, Baldelli Sara, Motterlini Nicola, Gotti Eliana, Sandrini Silvio, Salvadori Maurizio, Segoloni Giuseppe, Rigotti Paolo, Donati Donato, Perico Norberto, Remuzzi Giuseppe

Abstract excerpt

Cyclosporine A (CsA) is a substrate of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene. Compared with carriers of the wild-type gene, carriers of T allelic variants in exons 21 or 26 have reduced P-glycoprotein activity and, secondarily, increased intracellular concentration of CsA; therefore, carriers of T variants might be at increased risk for CsA-related adverse events. We evaluated the...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclosporine

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Share to Glomerular Filtration Rate

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Source

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Identifiers

PMID: 19470683
DOI: 10.1681/ASN.2008080819
PMCID: PMC2689900

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ABCB1 genotypes predict cyclosporine-related adverse events and kidney allograft outcome.PMID 19470683Read ↗

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