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Article

ABCB1 G2677 allele is associated with high dose requirement of cyclosporin A to prevent renal allograft rejection in North India.

Archives of medical research - 1 Oct 2008

Singh Ranjana, Kesarwani Pravin, Srivastava Aneesh, Mittal Rama Devi

Abstract excerpt

BACKGROUND: Interindividual heterogeneity in expression of ABCB1 gene has been suspected to be one of the factors resulting in cyclosporin (CsA) pharmacokinetic variation. The present study explored the association of ABCB1 SNPs on CsA dose requirements and dose-adjusted C2 levels (CsA level/daily dose requirement) in renal allograft recipients. METHODS: Daily doses (mg/kg/day) and dose-adjusted C2 levels...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18760199
DOI: 10.1016/j.arcmed.2008.06.008

Genes

ABCB1

Variants

Provenance

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ABCB1 G2677 allele is associated with high dose requirement of cyclosporin A to prevent renal allograft rejection in North India.PMID 18760199Read ↗

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