Article
The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.
Pharmacogenetics and genomics - 1 May 2012
Elens Laure, Bouamar Rachida, Hesselink Dennis A, Haufroid Vincent, van Gelder Teun, van Schaik Ron H N
Abstract excerpt
OBJECTIVE: Cyclosporine A (CsA) is a substrate of cytochrome P450 3A4 (CYP3A4). Recently, a newly discovered intron 6 single-nucleotide polymorphism in CYP3A4 (rs35599367 C>T), defining the CYP3A4*22 allele, has been linked to reduced hepatic expression and activity of CYP3A4. In the present stud...
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