Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study.

doi:10.1111/tri.12018

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Article

Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study.

Transplant international : official journal of the European Society for Organ Transplantation - 1 Feb 2013

Llaudó Inés, Colom Helena, Giménez-Bonafé Pepita, Torras Joan, Caldés Anna, Sarrias Maria, Cruzado Josep M, Oppenheimer Federico, Sánchez-Plumed Jaime, Gentil Miguel Ángel, Ekberg Henrik, Grinyó Josep M, Lloberas Núria

Abstract excerpt

The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to different immunosuppressive drugs in renal transplant patients....

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PMID: 23216707
DOI: 10.1111/tri.12018

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ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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