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Article

MDR1 haplotypes derived from exons 21 and 26 do not affect the steady-state pharmacokinetics of tacrolimus in renal transplant patients.

British journal of clinical pharmacology - 1 Nov 2004

Mai Ingrid, Perloff Elke S, Bauer Steffen, Goldammer Mark, Johne Andreas, Filler Guido, Budde Klemens, Roots Ivar

Abstract excerpt

AIM: This retrospective study investigated the influence of MDR1 haplotypes derived from the polymorphisms 2677G > T (exon 21) and 3435C > T (exon 26) on the pharmacokinetics of the immunosuppressant drug tacrolimus in 73 renal transplant patients. METHODS: Based on both variants of SNPs 2677 and 3435, four different haplotypes and eight different genotypes were identified in the study sample. Tacrolimus trough...

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Identifiers

PMID: 15521904
DOI: 10.1111/j.1365-2125.2004.02182.x
PMCID: PMC1884628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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