Article
ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation.
Journal of the American Society of Nephrology : JASN - 1 May 2005
Hauser Ingeborg A, Schaeffeler Elke, Gauer Stefan, Scheuermann Ernst H, Wegner Binytha, Gossmann Jan, Ackermann Hanns, Seidl Christian, Hocher Berthold, Zanger Ulrich M, Geiger Helmut, Eichelbaum Michel, Schwab Matthias
Abstract excerpt
Cyclosporine (CsA) nephrotoxicity is a severe complication in organ transplantation because it leads to impaired renal function and chronic allograft nephropathy, which is a major predictor of graft loss. Animal models and in vivo studies indicate that the transmembrane efflux pump P-glycoprotein contributes substantially to CsA nephrotoxicity. It was hypothesized that the TT genotype at the ABCB1 3435C-->T...
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