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Article

CYP3A4 genetic polymorphisms predict cyclosporine-related clinical events in Chinese renal transplant recipients.

Chinese medical journal - 1 Dec 2012

Wang Yu-Yuan, Zhang Ming, Lu Fu-Ming, Jiao Zheng, Qiu Xiao-Yan

Abstract excerpt

BACKGROUND: Cyclosporin A (CsA) is a substrate of both cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp), some of the single nucleotide polymorphisms (SNPs) in these genes are associated with interindividual variations in CsA pharmacokinetics. We studied the influence of these SNPs on the incidence of rejection and CsA nephrotoxicity, as well as pneumonia within one year after renal transplant and...

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PMID: 23217392

Genes

ABCB1

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