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Article

Association of Extrarenal Adverse Effects of Posttransplant Immunosuppression With Sex and ABCB1 Haplotypes.

Medicine - 1 Sept 2015

Venuto Rocco C, Meaney Calvin J, Chang Shirley, Leca Nicolae, Consiglio Joseph D, Wilding Gregory E, Brazeau Daniel, Gundroo Aijaz, Nainani Neha, Morse Sarah E, Cooper Louise M, Tornatore Kathleen M

Abstract excerpt

Extrarenal adverse effects (AEs) associated with calcineurin inhibitor (CNI) and mycophenolic acid (MPA) occur frequently but are unpredictable posttransplant complications. AEs may result from intracellular CNI accumulation and low activity of P-glycoprotein, encoded by the ABCB1 gene. Since ABCB1 single nucleotide polymorphisms (SNPs) and sex influence P-glycoprotein, we investigated haplotypes and extrarenal...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Calcineurin Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Haplotypes

Share to Immunosuppression Therapy

Share to Kidney Transplantation

Share to Mycophenolic Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 26376376
DOI: 10.1097/MD.0000000000001315
PMCID: PMC4635790

Genes

ABCB1

Variants

rs1128503
rs2032582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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