Article
ATP-binding cassette subfamily B member 1 polymorphisms do not determine cyclosporin exposure, acute rejection or nephrotoxicity after heart transplantation.
Transplantation - 15 Jan 2010
Taegtmeyer Anne B, Breen Jane B, Smith John, Burke Margaret, Leaver Neil, Pantelidis Panagiotis, Lyster Haifa, Yacoub Magdi H, Barton Paul J R, Banner Nicholas R
Abstract excerpt
BACKGROUND: We hypothesized that genetic variation of ATP-binding cassette subfamily B member 1 (ABCB1) that encodes P-glycoprotein (involved in the uptake of cyclosporin A [CsA]) contributes to trough drug concentrations and thereby to CsA's immunosuppressive and toxic effects. METHODS: Three hundred thirty-seven adult heart transplant recipients were studied retrospectively. White recipients receiving CsA at...
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