Article
Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers.
Drug metabolism letters - 1 Apr 2008
Ansermot Nicolas, Rebsamen Michela, Chabert Jocelyne, Fathi Marc, Gex-Fabry Marianne, Daali Youssef, Besson Marie, Rossier Michel, Rudaz Serge, Hochstrasser Denis, Dayer Pierre, Desmeules Jules
Abstract excerpt
The calcineurin inhibitor cyclosporine is removed from lymphocytes by the drug efflux transporter P-glycoprotein (P-gp) encoded by the ABCB1 gene for which several single nucleotide polymorphisms (SNPs) have been identified. Of a total of 87 healthy volunteers genotyped for ABCB1 G2677T/A and C3435T SNPs, 10 GG-CC and 9 TT-TT individuals were selected and received a single oral dose of cyclosporine. Peripheral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.