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Article

Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.

Molecular cancer research : MCR - 1 Jun 2009

McNeill Daniel R, Lam Wing, DeWeese Theodore L, Cheng Yung-Chi, Wilson David M

Abstract excerpt

Base excision repair (BER) is the major pathway for removing mutagenic and cytotoxic oxidative and alkylation DNA modifications. Using a catalytically inactive, dominant negative protein form of human APE1, termed ED, which binds with high affinity to substrate DNA and blocks subsequent repair steps, we assessed the role of BER in mediating cellular resistance to clinically relevant alkylating drugs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19470598
DOI: 10.1158/1541-7786.MCR-08-0519
PMCID: PMC2745049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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