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Article

The therapeutic potential ofO6-alkylguanine DNA alkyltransferase inhibitors

2007-10-01

Abstract excerpt

Resistance to O6-alkylating agents can be overcome by depletion of the DNA repair protein, O6-alkylguanine DNA alkyltransferase. Inhibitors of this protein act as pseudosubstrates and, so far, O6-benzylguanine and lomeguatrib have been tested in clinical trials. Inherently non-toxic, optimum doses for protein depletion have been established for both agents. Myelosuppression of alkylating agents is significantly en...

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Literature Corpus work
a89834a8-9cff-572a-94d4-45c23da98926
DOI
10.1517/13543784.16.10.1573
Open publication

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The therapeutic potential ofO6-alkylguanine DNA alkyltransferase inhibitorsDOI 10.1517/13543784.16.10.1573
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