Article

Versatile cell-based assay for measuring DNA alkylation damage and its repair

2021-02-25

Abstract excerpt

DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy. Base excision repair (BER) is a conserved, front line DNA repair pathway that removes alkylation damage from DNA. The capacity of BER to repair DNA alkylation varies markedly between different cell types and tissues, which correlates with...

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Literature Corpus work: 96eb8ccc-ced7-5cd6-bd4e-2066a21909a4
DOI: 10.1101/2021.02.25.432902

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