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Article

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.

BMC cancer - 8 Jan 2014

Xie Jiayin, Zhang Liang, Li Mengxia, Du Jia, Zhou Liwei, Yang Senlin, Zeng Linli, Li Zengpeng, Wang Ge, Wang Dong

Abstract excerpt

BACKGROUND: Melphalan resistance has been considered one of the major obstacles to improve outcomes in multiple myeloma (MM) therapy; unfortunately, the mechanistic details of this resistance remain unclear. Melphalan is a highly effective alkylating agent which causes many types of DNA lesions, including DNA base alkylation damage that is repaired by base excision repair (BER). We postulated that human...

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Share to Acetylation
Share to Antineoplastic Agents, Alkylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Gene Expression Regulation, Enzymologic

Share to Melphalan

Share to Multiple Myeloma

Source

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Identifiers

PMID: 24400589
DOI: 10.1186/1471-2407-14-11
PMCID: PMC3900260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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