Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells.

Clinical laboratory - 1 Jan 2015

Lin Ziying, Ren Nina, Jiang Yun, Xu Wenya, Shi Yapeng, Liu Gang

Abstract excerpt

BACKGROUND: E2F-1 is a transcription factor that stimulates cellular proliferation and cell cycle progression. E2F-1 alone is sufficient to stimulate cells to initiate DNA synthesis, and this unscheduled entry into S phase is a potent trigger of apoptosis. Gemcitabine, a novel pyrimidine analogue with structural and metabolic similarities to cytarabine, also can efficiently induce apoptosis, especially for cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Colonic Neoplasms
Share to Deoxycytidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to E2F1 Transcription Factor

Share to Gemcitabine

Share to Gene Transfer Techniques

Share to Inhibitory Concentration 50

Source

Identifiers

PMID: 26642705
DOI: 10.7754/clin.lab.2015.150104

Genes

DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenovirus-Mediated E2F-1 Gene Transfer Augments Gemcitabine-Induced Apoptosis in Human Colon Cancer Cells.PMID 26642705Read ↗

Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo.Semantic proximity Read ↗

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.Semantic proximity Read ↗

C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells.Semantic proximity Read ↗

Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.Semantic proximity Read ↗

A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses.Semantic proximity Read ↗

Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.Semantic proximity Read ↗

The Early Region 4 orf4 Protein of Human Adenovirus Type 5 Induces p53-Independent Cell Death by ApoptosisSemantic proximity Read ↗

Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs.Semantic proximity Read ↗

5‐Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell lineSemantic proximity Read ↗

AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells.Semantic proximity Read ↗

5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteinsSemantic proximity Read ↗

Efficient induction of apoptosis by ONYX-015 adenovirus in human colon cancer cell lines regardless of p53 status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.