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Article

APE1 overexpression promotes the progression of ovarian cancer and serves as a potential therapeutic target

26 Sept 2016

Abstract excerpt

BACKGROUND: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme that is involved in DNA repair and the redox regulation of transcription factors. Blocking these functions leads to cell-growth inhibition, apoptosis and other effects. Previous studies have demonstrated that high expression levels of the APE1 protein are associated with the progression and chemoresistance of cancers. We...

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PMID: 27802207
DOI: 10.3233/cbm-160643

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