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Article

The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Cortellino Salvatore, Turner David, Masciullo Valeria, Schepis Filippo, Albino Domenico, Daniel Rene, Skalka Anna Marie, Meropol Neal J, Alberti Christophe, Larue Lionel, Bellacosa Alfonso

Abstract excerpt

Cytotoxicity of methylating agents is caused mostly by methylation of the O6 position of guanine in DNA to form O6-methylguanine (O6-meG). O6-meG can direct misincorporation of thymine during replication, generating O6-meG:T mismatches. Recognition of these mispairs by the mismatch repair (MMR) system leads to cell cycle arrest and apoptosis. MMR also modulates sensitivity to other antitumor drugs. The base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14614141
DOI: 10.1073/pnas.2334585100
PMCID: PMC299910

Genes

MED1
MBD4
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity.PMID 14614141Read ↗

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