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Article

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

25 Jan 2011

Abstract excerpt

AIMS: Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In the current study, we aimed to develop small molecule inhibitors of APE1 for cancer therapy. METHODS: An...

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PMID: 21266972
DOI: 10.1038/sj.bjc.6606058

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