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O 6 -methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo

5 Jan 2009

Abstract excerpt

Alkylation-induced O(6)-methylguanine (O(6)MeG) DNA lesions can be mutagenic or cytotoxic if unrepaired by the O(6)MeG-DNA methyltransferase (Mgmt) protein. O(6)MeG pairs with T during DNA replication, and if the O(6)MeG:T mismatch persists, a G:C to A:T transition mutation is fixed at the next replication cycle. O(6)MeG:T mismatch detection by MutSalpha and MutLalpha leads to apoptotic cell death, but the...

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PMID: 19124772
DOI: 10.1073/pnas.0811991106

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