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Article

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009

Fernandez-Marcos Pablo J, Abu-Baker Shadi, Joshi Jayashree, Galvez Anita, Castilla Elias A, Cañamero Marta, Collado Manuel, Saez Carmen, Moreno-Bueno Gema, Palacios Jose, Leitges Michael, Serrano Manuel, Moscat Jorge, Diaz-Meco Maria T

Abstract excerpt

Prostate cancer is one of the most common neoplasias in men. The tumor suppressor Par-4 is an important negative regulator of the canonical NF-kappaB pathway and is highly expressed in prostate. Here we show that Par-4 expression is lost in a high percentage of human prostate carcinomas, and this occurs in association with phosphatase and tensin homolog deleted from chromosome 10 (PTEN) loss. Par-4 null mice,...

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Source

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Identifiers

PMID: 19470463
DOI: 10.1073/pnas.0813055106
PMCID: PMC2722271

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.PMID 19470463Read ↗

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