Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer resistance in transgenic mice expressing the SAC module of Par-4.

Cancer research - 1 Oct 2007

Zhao Yanming, Burikhanov Ravshan, Qiu Shirley, Lele Subodh M, Jennings C Darrell, Bondada Subbarao, Spear Brett, Rangnekar Vivek M

Abstract excerpt

Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal/immortalized cells. The cancer-specific proapoptotic action of Par-4 is encoded in its centrally located SAC domain. We report here the characterization of a novel mouse model with ubiquitous expression of the SAC domain. Although SAC transgenic mice displayed normal development and life...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Neoplasms, Experimental

Share to Protein Structure, Tertiary

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 17909035
DOI: 10.1158/0008-5472.CAN-07-2124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer resistance in transgenic mice expressing the SAC module of Par-4.PMID 17909035Read ↗

Apoptosis and tumor resistance conferred by Par-4Semantic proximity Read ↗

Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymoreSemantic proximity Read ↗

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells.Semantic proximity Read ↗

Tumour-suppression activity of the proapoptotic regulator Par4.Semantic proximity Read ↗

Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor PrognosisSemantic proximity Read ↗

Par-4 overexpression impedes leukemogenesis in the Eµ-TCL1 leukemia model through downregulation of NF-κB signalingSemantic proximity Read ↗

Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemiaSemantic proximity Read ↗

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.Semantic proximity Read ↗

Mechanisms of apoptosis by the tumor suppressor Par-4.Semantic proximity Read ↗

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancerSemantic proximity Read ↗

Dampened PI3K/AKT signaling contributes to cancer resistance of the naked mole ratSemantic proximity Read ↗

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.