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Article

Cytosolic phospholipase A2α sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells.

Biochimica et biophysica acta - 1 Jun 2013

Hua Sheng, Yao Mu, Vignarajan Soma, Witting Paul, Hejazi Leila, Gong Zhen, Teng Ying, Niknami Marzieh, Assinder Stephen, Richardson Des, Dong Qihan

Abstract excerpt

Constitutive phosphorylation of protein kinase B (AKT) is a common feature of cancer caused by genetic alteration in the phosphatase and tensin homolog (PTEN) gene and is associated with poor prognosis. This study determined the role of cytosolic phospholipase A2α (cPLA2α) in AKT, extracellular signal-regulated kinase (ERK) and androgen receptor (AR) signaling in PTEN-null/mutated prostate cancer cells....

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Source

Identifiers

PMID: 23500889
DOI: 10.1016/j.bbalip.2013.02.011

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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