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Article

Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia

25 Apr 2018

Abstract excerpt

Prostate apoptosis response-4 (Par-4), a proapoptotic tumor suppressor protein, is downregulated in many cancers including renal cell carcinoma, glioblastoma, endometrial, and breast cancer. Par-4 induces apoptosis selectively in various types of cancer cells but not normal cells. We found that chronic lymphocytic leukemia (CLL) cells from human patients and from Eµ-Tcl1 mice constitutively express Par-4 in...

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PMID: 29695515
DOI: 10.1182/blood-2017-10-813931

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