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Article

Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.

Cancer research - 15 Feb 2006

Zhong Chen, Saribekyan Gohar, Liao Chun-Peng, Cohen Michael B, Roy-Burman Pradip

Abstract excerpt

Two commonly occurring genetic aberrations of human prostate cancer [i.e., overexpression of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of function of PTEN tumor suppressor] were recapitulated into a new combinatorial mouse model. This model harboring the Fgf8b transgene and haploinsufficiency in Pten, both in a prostate epithelium-specific manner, yielded prostatic...

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Source

Identifiers

PMID: 16489020
DOI: 10.1158/0008-5472.CAN-05-3440

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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