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Article

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2002

Kim Minjung J, Cardiff Robert D, Desai Nishita, Banach-Petrosky Whitney A, Parsons Ramon, Shen Michael M, Abate-Shen Cory

Abstract excerpt

Mouse models have provided significant insights into the molecular mechanisms of tumor suppressor gene function. Here we use mouse models of prostate carcinogenesis to demonstrate that the Nkx3.1 homeobox gene undergoes epigenetic inactivation through loss of protein expression. Loss of function of Nkx3.1 in mice cooperates with loss of function of the Pten tumor suppressor gene in cancer progression. This...

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Source

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Identifiers

PMID: 11854455
DOI: 10.1073/pnas.042688999
PMCID: PMC122442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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