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Article

Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer

1 Apr 2008

Abstract excerpt

To identify biomarkers that discriminate the aggressive forms of prostate cancer, we performed gene expression profiling of prostate tumors using a genetically engineered mouse model that recapitulates the stages of human prostate cancer, namely Nkx3.1; Pten mutant mice. We observed a significant deregulation of the epidermal growth factor and mitogen-activated protein kinase (MAPK) signaling pathways, as well as...

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PMID: 18381418
DOI: 10.1158/0008-5472.can-07-6055

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