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Article

Tumour-suppression activity of the proapoptotic regulator Par4.

EMBO reports - 1 Jun 2005

García-Cao Isabel, Duran Angeles, Collado Manuel, Carrascosa Maria J, Martín-Caballero Juan, Flores Juana M, Diaz-Meco Maria T, Moscat Jorge, Serrano Manuel

Abstract excerpt

The proapoptotic protein encoded by Par4 (prostate apoptosis response 4) has been implicated in tumour suppression, particularly in the prostate. We report here that Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-null females...

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Source

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Identifiers

PMID: 15877079
DOI: 10.1038/sj.embor.7400421
PMCID: PMC1369092

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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