Article
Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1991
Höglund P, Ohlén C, Carbone E, Franksson L, Ljunggren H G, Latour A, Koller B, Kärre K
Abstract excerpt
The role of major histocompatibility complex (MHC) class I expression in control of the sensitivity of normal cells to natural killer (NK) cells was studied by the use of mutant mice made deficient for expression of beta 2-microglobulin (beta 2m) through homologous recombination in embryonal stem...
Topics
- Animals
- Antibodies, Monoclonal
- Bone Marrow
- Cell Line
- Chimera
- Concanavalin A
- Cytotoxicity, Immunologic
- Flow Cytometry
- Killer Cells, Natural
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Phenotype