The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts.

doi:10.1016/s1074-7613(00)80299-x

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Article

The role of Ly49A and 5E6(Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts.

Immunity - 1 Jan 1996

Yu Y Y, George T, Dorfman J R, Roland J, Kumar V, Bennett M

Abstract excerpt

We address the mechanism of hybrid resistance (HR) in vitro using NK effector cells and target lymphoblasts from H-2b, H-2d, and H-2b/d mice. The 5E6 (Ly49C)+ subset of F1 NK cells lyse BALB/c (H-2d) but not B6 (H-2b) targets unless either anti-5E6 or anti-H-2Kb MAbs are present. H-2Dd transgenic...

Topics

Alleles
Animals
Antigens, Ly
Cytotoxicity, Immunologic
Killer Cells, Natural
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
T-Lymphocytes

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