Article
PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.
Inflammatory bowel diseases - 1 Oct 2009
Zucchelli Marco, Torkvist Leif, Bresso Francesca, Halfvarson Jonas, Hellquist Anna, Anedda Francesca, Assadi Ghazaleh, Lindgren Gunnar B, Svanfeldt Monika, Janson Martin, Noble Colin L, Pettersson Sven, Lappalainen Maarit, Paavola-Sakki Paulina, Halme Leena, Färkkilä Martti, Turunen Ulla, Satsangi Jack, Kontula Kimmo, Löfberg Robert, Kere Juha, D'Amato Mauro
Abstract excerpt
BACKGROUND: Human polymorphisms affecting gut epithelial barrier and interactions with bacteria predispose to the inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC). The intestinal transporter PepT1, encoded by the SLC15A1 gene, mediates intracellular uptake of bacterial products that can induce inflammation and NF-kappaB activation upon binding to NOD2, a protein often mutated in...
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