Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation.

PloS one - 1 Jan 2014

Wei Shu-Chen, Tan Yan-Yin, Weng Meng-Tzu, Lai Liang-Chuan, Hsiao Jen-Hao, Chuang Eric Y, Shun Chia-Tung, Wu Deng-Cheng, Kao Ai-Wen, Chuang Chiao-Shung, Ni Yen-Hsuan, Shieh Ming-Jium, Tung Chien-Chih, Chen Yun, Wang Cheng-Yi, Xavier Ramnik J, Podolsky Daniel K, Wong Jau-Min

Abstract excerpt

BACKGROUND & AIMS: To date, only one gene (TNFSF15) has been identified and validated as a Crohn's disease (CD)-associated gene in non-Caucasian populations. This study was designed to identify novel CD-associated single nucleotide polymorphisms (SNPs)/genes and to validate candidate genes using a functional assay. METHODS: SNPs from 16 CD patients and 16 age- and sex-matched control patients were analyzed using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crohn Disease
Share to Demography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Mitogen-Activated Protein Kinases

Share to NF-kappa B

Share to Nicotine

Share to Organic Anion Transporters

Share to Proto-Oncogene Proteins c-akt

Source

Open in PubMed Open full text

Identifiers

PMID: 24945726
DOI: 10.1371/journal.pone.0100515
PMCID: PMC4063938

Genes

TNFSF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLCO3A1, A novel crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation.PMID 24945726Read ↗

Polymorphisms of the TNF Gene and Three Susceptibility Loci Are Associated with Crohn's Disease and Perianal Fistula Crohn's Disease: A Study among the Han Population from South China.Semantic proximity Read ↗

A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.Semantic proximity Read ↗

TNFSF15 is an independent predictor for the development of Crohn's disease-related complications in Koreans.Semantic proximity Read ↗

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.Semantic proximity Read ↗

Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population.Semantic proximity Read ↗

Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis.Semantic proximity Read ↗

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.Semantic proximity Read ↗

Association of TNFSF15 polymorphisms in Korean children with Crohn's disease.Semantic proximity Read ↗

Polymorphism rs6478109 in the TNFSF15 gene contributes to the susceptibility to Crohn's disease but not ulcerative colitis: a meta-analysis.Semantic proximity Read ↗

Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysisSemantic proximity Read ↗

Association of TNFSF15 with Crohn's disease in Koreans.Semantic proximity Read ↗

Association of TNFSF15 polymorphism with irritable bowel syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.