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Article

Functional variants of OCTN cation transporter genes are associated with Crohn disease.

Nature genetics - 1 May 2004

Peltekova Vanya D, Wintle Richard F, Rubin Laurence A, Amos Christopher I, Huang Qiqing, Gu Xiangjun, Newman Bill, Van Oene Mark, Cescon David, Greenberg Gordon, Griffiths Anne M, St George-Hyslop Peter H, Siminovitch Katherine A

Abstract excerpt

Crohn disease is a chronic, inflammatory disease of the gastrointestinal tract. A locus of approximately 250 kb at 5q31 (IBD5) was previously associated with susceptibility to Crohn disease, as indicated by increased prevalence of a risk haplotype of 11 single-nucleotide polymorphisms among individuals with Crohn disease, but the pathogenic lesion in the region has not yet been identified. We report here that two...

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PMID: 15107849
DOI: 10.1038/ng1339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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