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Article

Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene.

Journal of gastroenterology - 1 Sept 2011

Repnik Katja, Potočnik Uroš

Abstract excerpt

BACKGROUND: The IBD5 locus (OMIM ID 606348) on chromosome 5 was suggested to be one of the most important genetic factors involved in the pathogenesis of inflammatory bowel diseases (IBDs). However the main contributor from this region is still unknown. METHODS: We investigated the possible association of the IBD5 locus with IBD in Slovenian patients and correlation between disease-associated single nucleotide...

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PMID: 21695374
DOI: 10.1007/s00535-011-0426-6

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