Article
Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.
Alimentary pharmacology & therapeutics - 15 Feb 2006
Palmieri O, Latiano A, Valvano R, D'Incà R, Vecchi M, Sturniolo G C, Saibeni S, Peyvandi F, Bossa F, Zagaria C, Andriulli A, Devoto M, Annese V
Abstract excerpt
BACKGROUND: Two variants in the organic cation transporter gene cluster have been recently reported to confer susceptibility to Crohn's disease (CD). AIM: To investigate these variants in CD and ulcerative colitis (UC), and their interaction with CARD15 gene and correlation to clinical subphenotypes. METHODS: Case-control association analysis was performed in 899 patients (444 CD and 455 UC) and 611 controls. The...
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