Article
Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes.
The Journal of surgical research - 15 Jun 2017
Connelly Tara M, Choi Christine S, Berg Arthur S, Harris Leonard, Coble Joel, Koltun Walter A
Abstract excerpt
BACKGROUND: Diverticulitis (DD) and Crohn's disease (CD) have overlapping features including bowel structuring, inflammation, and infection. Tumor necrosis superfamily 15 (TNFSF15) is an immunoregulatory, anti-angiogenic gene. CD has been previously associated with a haplotype of five TNFSF15 single-nucleotide polymorphism alleles: rs3810936 (G allele), rs6478108 (A), rs6478109 (G), rs7848647 (G), and rs7869487...