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Article

Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.

Arthritis and rheumatism - 1 Nov 2005

Ho Pauline, Bruce Ian N, Silman Alan, Symmons Deborah, Newman Bill, Young Helen, Griffiths Christopher E M, John Sally, Worthington Jane, Barton Anne

Abstract excerpt

OBJECTIVE: Clinical, pharmacologic, and epidemiologic evidence supports the hypothesis that common genetic pathways may underlie inflammatory diseases. In a previous study, a Crohn's disease gene, CARD15, was demonstrated to be associated with psoriatic arthritis (PsA). Recently, a functional haplotype of 2 single-nucleotide polymorphisms (SNPs) mapping to the organic cation transporter (OCTN) genes, SLC22A4 and...

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Identifiers

PMID: 16255050
DOI: 10.1002/art.21393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.PMID 16255050Read ↗

Functional variants of OCTN cation transporter genes are associated with Crohn disease.Semantic proximity Read ↗

CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis.Semantic proximity Read ↗

Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population.Semantic proximity Read ↗

The 5q31 variants associated with psoriasis and Crohn's disease are distinct.Semantic proximity Read ↗

Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.Semantic proximity Read ↗

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.Semantic proximity Read ↗

Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.Semantic proximity Read ↗

PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease.Semantic proximity Read ↗

Genetic and environmental factors in monozygotic twins with Crohn's disease and their first-degree relatives: a case report.Semantic proximity Read ↗

CARD15/NOD2 single nucleotide polymorphisms do not confer susceptibility to type I psoriasis.Semantic proximity Read ↗

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