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Article

Adaptive variation regulates the expression of the human SGK1 gene in response to stress.

PLoS genetics - 1 May 2009

Luca Francesca, Kashyap Sonal, Southard Catherine, Zou Min, Witonsky David, Di Rienzo Anna, Conzen Suzanne D

Abstract excerpt

The Serum and Glucocorticoid-regulated Kinase1 (SGK1) gene is a target of the glucocorticoid receptor (GR) and is central to the stress response in many human tissues. Because environmental stress varies across habitats, we hypothesized that natural selection shaped the geographic distribution of genetic variants regulating the level of SGK1 expression following GR activation. By combining population genetics and...

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Source

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Identifiers

PMID: 19461886
DOI: 10.1371/journal.pgen.1000489
PMCID: PMC2679193

Genes

SGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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